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Invitrogen
E-selectin Polyclonal Antibody, Biotin
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产品信息
PA1-40301
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Human E-Selectin.
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
PA1-40301 detects E-Selectin from human, chimpanzee, rhesus monkey, cynomolgous monkey and baboon samples.
PA1-40301 reacts with the Lectin Domain of E-selectin, CD62-e, formerly designated Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1). PA1-40301 reacts with human endothelial cells activated with TNF, IL-1 or endotoxin. PA1-40301 was found to react also with cells transfected with the ELAM-1 gene. The antibody inhibits the adhesion of granulocytes both neutrophilic and eosinophilic.
PA1-40301 has been successfully used in ELISA, immunohistochemistry (frozen) and Western blot applications. It is recommended that users test the reagent and determin their own optimal dilutions: the typical starting working dilution is 1:10.
The PA1-40301 imunogen is human E-Selectin.
靶标信息
Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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