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Proteintech
EAF2 Polyclonal Antibody
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产品信息
11172-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EAF2 Fusion Protein Ag1637 (1-260 aa encoded by BC014209)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
11172-1-AP is a rabbit polyclonal antibody raised against the full-length human EAF2 protein.
Immunogen sequence: MNSAAGFSH LDRRERVLKL GESFEKQPRC AFHTVRYDFK PASIDTSSEG YLEVGEGEQV TITLPNIEGS TPPVTVFKGS KKPYLKECIL IINHDTGECR LEKLSSNITV KKTRVEGSSK IQYRKEQQQQ QMWNSARTPN LVKHSPSEDK MSPASPIDDI ERELKAEASL MDQMSSCDSS SDSKSSSSSS SEDSSSDSED EDCKSSTSDT GNCVSGHPTM TQYRIPDIDA SHNRFRDNSG LLMNTLRNDL QLSESGSDSD D (1-260 aa encoded by BC014209)
靶标信息
EAF1 and EAF2 can form a complex with ELL that targets the ternary elongation complex of Pol II, stimulating the rate of elongation. In addition, EAF1 and EAF2 are important for the stability of the NuA4 histone acetyltransferase complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. Both EAF1 and EAF2 are ubiquitously expressed members of the EAF family that colocalize with ELL to the the Cajal bodies and nuclear speckles. EAF1 contains a C-terminal region rich in aspartic acid, glutamic acid and serine residues. EAF2 is an androgen-response gene and can act as a potent apoptosis inducer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ehrlich S-II transcriptional activator factor; ELL-associated factor 2; testosterone regulated apoptosis inducer and tumor suppressor; Testosterone-regulated apoptosis inducer and tumor suppressor protein
基因别名: AW048865; BM-040; BM040; EAF2; Festa; FESTA-L; FESTA-S; TRAITS; U19
UniProt ID: (Human) Q96CJ1, (Mouse) Q91ZD6, (Rat) Q811X5
Entrez Gene ID: (Human) 55840, (Mouse) 106389, (Rat) 266787
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell growth
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of epithelial cell proliferation involved in prostate gland development
intrinsic apoptotic signaling pathway
apoptotic process
biological_process
