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Invitrogen
EFHD2 Polyclonal Antibody
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EFHD2 Antibody (PA5-78575) in ICC/IF
EFHD2 Polyclonal Antibody detects EFHD2 protein by immunofluorescent analysis. Sample: DIV14 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green: EFHD2 protein stained by EFHD2 Polyclonal Antibody (Product # PA5-78575) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta-3 Tubulin Polyclonal Antibody [GT1338]diluted at 1:500. Blue: Fluoroshield with DAPI .
产品信息
PA5-78575
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human EFHD2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: H1299, HeLaS3, mouse brain, rat brain
Predicted Reactivity: Rhesus Monkey (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EF hand domain containing 2; EF hand domain family, member D2; EF-hand domain family, member D2; EF-hand domain-containing protein D2; MGC4342; RP3-467K16.3; swiprosin 1; Swiprosin-1; testicular tissue protein Li 62
基因别名: 2600015J22Rik; AA408606; D4Wsu27e; EFHD2; SWS1
UniProt ID: (Human) Q96C19, (Rat) Q4FZY0
Entrez Gene ID: (Human) 79180, (Mouse) 27984, (Rat) 298609
