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Abnova
EGF Monoclonal Antibody (2F1)
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产品信息
H00001950-M01J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
2F1
抗原
EGF (NP_001954, 926 a.a. approximately 1025 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: NASCTNTEGG YTCMCAGRLS EPGLICPDST PPPHLREDDH HYSVRNSDSE CPLSHDGYCL HDGVCMYIEA LDKYACNCVV GYIGERCQYR DLKWWKLRHA
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-urogastrone; EGF; Epidermal growth factor; H-EGF; Pro-epidermal growth factor
基因别名: EGF; HOMG4; URG
UniProt ID: (Human) P01133
Entrez Gene ID: (Human) 1950
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
epidermal growth factor receptor binding
calcium ion binding
protein binding
growth factor activity
Wnt-protein binding
transmembrane receptor protein tyrosine kinase activator activity
Wnt-activated receptor activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
transmembrane signal receptor
MAPK cascade
activation of MAPKK activity
activation of MAPK activity
angiogenesis
platelet degranulation
DNA replication
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
epidermal growth factor receptor signaling pathway
STAT protein import into nucleus
positive regulation of cell proliferation
positive regulation of peptidyl-threonine phosphorylation
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
positive regulation of cerebellar granule cell precursor proliferation
positive regulation of catenin import into nucleus
ERBB2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of phosphorylation
positive regulation of DNA binding
positive regulation of MAP kinase activity
positive regulation of GTPase activity
Wnt signaling pathway involved in dorsal/ventral axis specification
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
branching morphogenesis of an epithelial tube
negative regulation of secretion
canonical Wnt signaling pathway
mammary gland alveolus development
ERK1 and ERK2 cascade
regulation of calcium ion import
negative regulation of cholesterol efflux
positive regulation of hyaluronan biosynthetic process
regulation of protein localization to cell surface
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of cell motility
