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Invitrogen
ENY2 Polyclonal Antibody
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产品信息
PA5-115182
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ENY2(Accession Q9NPA8), corresponding to amino acid residues H49-A99.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ENY2.
靶标信息
ENY2 is a component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: e(y)2 homolog; e(y)2 protein; enhancer of yellow 2 homolog; Enhancer of yellow 2 transcription factor homolog; enhancer of yellow eye homolog; ENY 2; ENY-2; ENY2; Transcription and mRNA export factor ENY2
基因别名: 1810057B09Rik; 6720481I12; DC6; e(y)2; ENY2; Ey2; Sus1
UniProt ID: (Human) Q9NPA8, (Mouse) Q9JIX0
Entrez Gene ID: (Human) 56943, (Rat) 685258, (Mouse) 223527
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein transport
histone deubiquitination
poly(A)+ mRNA export from nucleus
positive regulation of transcription, DNA-templated
negative regulation of insulin secretion involved in cellular response to glucose stimulus
mRNA export from nucleus
transcription, DNA-templated
regulation of transcription, DNA-templated
transport
chromatin modification
mRNA transport
