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Invitrogen
EPS15 Polyclonal Antibody
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图: 1 / 2
EPS15 Antibody (PA5-79216) in WB
Western blot analysis of EPS15 in Lane 1: rat brain tissue lysate, Lane 2: rat liver tissue lysate, Lane 3: mouse brain tissue lysate, Lane 4: mouse spleen tissue lysate, Lane 5: mouse liver tissue lysate, Lane 6: mouse testis tissue lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79216
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human EPS15 recombinant protein (Position: A2-E88).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human A375 whole cell, human HepG2 whole cell, human Jurkat whole cell, human PANC-1 whole cell, rat brain tissue, rat liver tissue, mouse brain tissue, mouse spleen tissue, mouse liver tissue, mouse testis tissue.
靶标信息
EPS15 is a ubiquitously expressed protein that is involved in cell growth regulation and may be involved in the regulation of mitogenic signals and control of cell proliferation. Phosphorylation of EPS15 on Tyrosine 849 upon DNA damage is involved in the internalization of EGFR. A chromosomal aberration involving EPS15 is also found in acute leukemias, resulting in a rogue activator protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: accessory endocytosis protein; AF-1p; AF-1p protein; ALL1 fused gene from chromosome 1; EBS15B; trafficking protein; COMP-binding protein; alternatively spliced; epidermal growth factor pathway substrate 15; protein AF-1p; unnamed protein product
基因别名: 2410112D09Rik; AF-1P; AF1P; MLLT5; RGD1307641
UniProt ID: (Human) P42566, (Mouse) P42567
Entrez Gene ID: (Human) 2060, (Rat) 313474, (Mouse) 13858
positive regulation of receptor recycling
Golgi to endosome transport
endocytosis
endosomal transport
receptor-mediated endocytosis of virus by host cell
endocytic recycling
regulation of protein localization
regulation of cell proliferation
viral entry into host cell
clathrin coat assembly
ubiquitin-dependent endocytosis
postsynaptic neurotransmitter receptor internalization
vesicle organization
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
