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Invitrogen
ERCC1 Monoclonal Antibody (8F1)
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ERCC1 Antibody (MA5-13912) in IHC (P)
Immunohistochemistry analysis of ERCC1 showing positive staining in the nucleus and cytoplasm of paraffin-treated Human lung adenocarcinoma (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0) microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2... View More
产品信息
MA5-13912
应用
建议稀释比
已发表文章
产品规格
已发表种属
Hamster,
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
8F1
抗原
Recombinant full length human ERCC1 protein
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-13912 targets ERCC1 in IP, IHC (P), FACS and WB applications and shows reactivity with human, mouse and rat samples.
The MA5-13912 immunogen is recombinant full length human ERCC1 protein.
靶标信息
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)
仅用于科研。不用于诊断过程。未经明确授权不得转售。
