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Invitrogen
ERN2 Polyclonal Antibody
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产品信息
PA5-53442
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human ERN2
偶联物
形式
Liquid
浓度
0.05 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: SPGKYMSHLA SCGMGLLLTV DPGSGTVLWT QDLGVPVMGV YTWHQDGLRQ LPHLTLARDT LHFLALRWGH IRLPASGPRD TATLFSTLDT QLLMTLYVGK DETGFYVSKA LVHTGVALVP RGLTLAPADG PTT
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.
靶标信息
ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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