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Proteintech
ETV5 Monoclonal Antibody (2A4A4)
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产品信息
66657-1-IG
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
2A4A4
抗原
ETV5 Fusion Protein Ag3708 (160-510 aa encoded by BC007333)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SGHAPAAGP VQGVGPAPAP HSLPEPGPQQ QTFAVPRPPH QPLQMPKMMP ENQYPSEQRF QRQLSEPCHP FPPQPGVPGD NRPSYHRQMS EPIVPAAPPP PQGFKQEYHD PLYEHGVPGM PGPPAHGFQS PMGIKQEPRD YCVDSEVPNC QSSYMRGGYF SSSHEGFSYE KDPRLYFDDT CVVPERLEGK VKQEPTMYRE GPPYQRRGSL QLWQFLVTLL DDPANAHFIA WTGRGMEFKL IEPEEVARRW GIQKNRPAMN YDKLSRSLRY YYEKGIMQKV AGERYVYKFV CDPDALFSMA FPDNQRPFLK AESECHLSEE DTLPLTHFED SPAYLLDMDR CSSLPYAEGF AY (160-510 aa encoded by BC007333)
靶标信息
ETS variant 5, transcription factor of the ETS family, divergent member of the winged helix-turn-helix superfamily, expressed in brain, placenta and other tissues involved in development. Tissue specificity: Ubiquitous. ERM is expressed in Sertoli cells and spermatogonial stem cells (SSCs). Studies on knockout mice have shown that it is required for SSC self-renewal but not differentiation, thus affected mice exhibit progressive germ cell depletion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ETS translocation variant 5; ets-related molecule; Ets-related protein ERM
基因别名: ERM; ETV5
UniProt ID: (Human) P41161
Entrez Gene ID: (Human) 2119
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
transcription from RNA polymerase II promoter
neuromuscular synaptic transmission
locomotory behavior
cell differentiation
cellular response to oxidative stress
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
male germ-line stem cell asymmetric division
regulation of synapse organization
positive regulation of glial cell proliferation
regulation of branching involved in mammary gland duct morphogenesis
skeletal muscle acetylcholine-gated channel clustering
