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Abnova
EXDL2 Polyclonal Antibody, MaxPab™
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产品信息
H00055218-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EXDL2 (NP_060669.1, 1 a.a. approximately 496 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MASPSGLCVL VRLPKLICGG KTLPRTLLDI LADGTILKVG VGCSEDASKL LQDYGLVVRG CLDLRYLAMR QRNNLLCNGL SLKSLAETVL NFPLDKSLLL RCSNWDAETL TEDQVIYAAR DAQISVALFL HLLGYPFSRN SPGEKNDDHS SWRKVLEKCQ GVVDIPFRSK GMSRLGEEVN GEATESQQKP RNKKSKMDGM VPGNHQGRDP RKHKRKPLGV GYSARKSPLY DNCFLHAPDG QPLCTCDRRK AQWYLDKGIG ELVSEEPFVV KLRFEPAGRP ESPGDYYLMV KENLCVVCGK RDSYIRKNVI PHEYRKHFPI EMKDHNSHDV LLLCTSCHAI SNYYDNHLKQ QLAKEFQAPI GSEEGLRLLE DPERRQVRSG ARALLNAESL PTQRKEELLQ ALREFYNTDV VTEEMLQEAA SLETRISNEN YVPHGLKVVQ CHSQGGLRSL MQLESRWRQH FLDSMQPKHL PQQWSVDHNH QKLLRKFGED LPIQLS
靶标信息
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3'-5' exoribonuclease EXD2; Exonuclease 3'-5' domain-containing protein 2; exonuclease 3'-5' domain-like 2; Exonuclease 3'-5' domain-like-containing protein 2
基因别名: C14orf114; EXD2; EXDL2
UniProt ID: (Human) Q9NVH0
Entrez Gene ID: (Human) 55218
