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Invitrogen
Endothelin A Receptor Recombinant Rabbit Monoclonal Antibody (15H24L16)
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图: 1 / 5
Endothelin A Receptor Antibody (704014) in ICC/IF
HEK-293 cells stably transfected with EDNRA were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with EDNRA Recombinant Rabbit Monoclonal Antibody (Prod... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
704014
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
15H24L16
抗原
Peptide corresponding to residues aa 408-427 of human EDNRA
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Endothelin A; endothelin receptor subtype A; endothelin-1-specific receptor; ET-AR; ET-AR delta 3-4; ET-AR delta 4; G protein-coupled receptor; G-protein coupled receptor; unnamed protein product
基因别名: ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA
UniProt ID: (Human) P25101
Entrez Gene ID: (Human) 1909
mitotic cell cycle
angiogenesis
patterning of blood vessels
blood vessel remodeling
response to amphetamine
regulation of heart rate
heart process
glomerular filtration
cardiac chamber formation
left ventricular cardiac muscle tissue morphogenesis
atrial cardiac muscle tissue development
cardiac neural crest cell migration involved in outflow tract morphogenesis
noradrenergic neuron differentiation
cellular calcium ion homeostasis
smooth muscle contraction
mitochondrion organization
signal transduction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
axon guidance
heart development
respiratory gaseous exchange
regulation of blood pressure
cell proliferation
response to wounding
gene expression
neural crest cell differentiation
neural crest cell fate commitment
artery smooth muscle contraction
vascular smooth muscle contraction
neuron remodeling
thyroid gland development
neuron projection development
glomerulus development
cellular response to oxidative stress
embryonic heart tube development
aorta development
vasoconstriction
norepinephrine metabolic process
middle ear morphogenesis
cellular response to human chorionic gonadotropin stimulus
developmental pigmentation
enteric nervous system development
sympathetic nervous system development
axon extension
embryonic skeletal system development
neuromuscular process
sodium ion homeostasis
canonical Wnt signaling pathway
face development
axonogenesis involved in innervation
pharyngeal arch artery morphogenesis
renal sodium ion absorption
calcium ion transmembrane transport
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
semaphorin-plexin signaling pathway
glomerular endothelium development
glomerular visceral epithelial cell differentiation
endothelin receptor signaling pathway
renal albumin absorption
vascular smooth muscle cell development
mesenchymal cell apoptotic process
cellular response to toxic substance
sympathetic neuron axon guidance
cAMP/PKA signal transduction
glomerular visceral epithelial cell apoptotic process
meiotic cell cycle process involved in oocyte maturation
cranial skeletal system development
response to acetylcholine
regulation of protein localization to cell leading edge
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