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Enterotoxin A, primarily produced by Staphylococcus aureus, is a potent exotoxin responsible for food poisoning and toxic shock syndrome. The gene encoding Enterotoxin A, known as entA, is chromosomally mapped in S. aureus strains, with its expression leading to the secretion of this macro-protein. Structurally, Enterotoxin A is a polypeptide that alters intestinal salt and water transport, causing diarrhea without affecting mucosal morphology. The toxin domain interacts with receptor proteins, facilitating its pathogenic effects. The molecular structure of Enterotoxin A includes a beta-barrel channel-forming toxin, which is crucial for its function. This enterotoxin is part of a broader group of toxins produced by various bacteria, including Escherichia coli and Vibrio cholerae, each with distinct mechanisms of action.
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