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Invitrogen
Ephrin A5 Polyclonal Antibody
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FIGURE: 1 / 5
Ephrin A5 Antibody (PA5150136) in IHC (P)
Immunohistochemistry analysis of Ephrin A5 in paraffin-embedded Human Bile duct cancer tissue. Samples were incubated with Ephrin A5 Polyclonal (Product # PA5150136) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5150136
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Ephrin A5 (EFNA5) (Gln21-Asn203)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Ephrin A5 is a cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AL-1; EPH-related receptor tyrosine kinase ligand 7; Ephrin-A5; LERK-7
Gene Aliases: AF1; EFL5; EFNA5; EPLG7; GLC1M; LERK7; RAGS
UniProt ID: (Human) P52803, (Rat) P97605
Entrez Gene ID: (Human) 1946, (Rat) 116683
positive regulation of protein phosphorylation
apoptotic process
activation of transmembrane receptor protein tyrosine kinase activity
nervous system development
axon guidance
regulation of cell-cell adhesion
regulation of cell morphogenesis
retinal ganglion cell axon guidance
regulation of actin cytoskeleton organization
regulation of GTPase activity
ephrin receptor signaling pathway
collateral sprouting
positive regulation of collateral sprouting
positive regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
regulation of focal adhesion assembly
positive regulation of synapse assembly
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of microtubule cytoskeleton organization
negative regulation of substrate adhesion-dependent cell spreading
axonal fasciculation
central nervous system development
brain development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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