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Invitrogen
ErbB3 Polyclonal Antibody
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ErbB3 Antibody (PA1-30497)
IP-MS enrichment of ERBB3 (LFQ intensity): ERBB3 was enriched 802-fold from MCF7 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Product # 90409) and ERBB3 antibody (Product # PA1-30497). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of anti... View More
产品信息
PA1-30497
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues A(71) M N E F S T L P L P N L R V V(86) C of the ligand binding domain of human c-erbB-3/HER-3 oncoprotein.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
PA1-30497 detects c-ErbB3 from human samples.
PA1-30497 has been successfully used in immunoprecipitation and immunohistochemistry (paraffin tissue) applications.
The PA1-30497 immunogen is: Synthetic peptide corresponding to residues A(71) M N E F S T L P L P N L R V V(86) C of the ligand binding domain of human c-erbB-3/HER-3 oncoprotein.
靶标信息
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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