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GenScript
Evolocumab Recombinant Rabbit Monoclonal Antibody (39B8), MonoRab™
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Evolocumab Antibody (A02293-40) in ELISA
BLI (Biolayer interferometry) binding affinity measurements of MonoRab™ Anti-Evolocumab Antibody (39B8), mAb, Rabbit (GenScript, A02293) to Evolocumab. Evolocumab captured on HFC (Anti-Human IgG Fc) Probes can bind MonoRab™ Anti-Evolocumab Antibody (39B8), mAb, Rabbit with a dissociation constant (KD) of less than 1 pM.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
A02293-40
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
Mammalian cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
39B8
抗原
Evolocumab
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
40 µg
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
Sandwich ELISA recommended dilution: 0.5-2 µg/mL; Competitive ELISA recommended dilution: 1-10 µg/mL
The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
靶标信息
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; neural apoptosis regulated convertase 1; OTTHUMP00000009833; subtilisin/kexin-like protease PC9; unnamed protein product
基因别名: FH3; FHCL3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9
UniProt ID: (Human) Q8NBP7
Entrez Gene ID: (Human) 255738
RNA binding
endopeptidase activity
serine-type endopeptidase activity
protein binding
serine-type peptidase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
transporter inhibitor activity
kidney development
liver development
negative regulation of receptor recycling
negative regulation of receptor internalization
positive regulation of receptor internalization
proteolysis
lysosomal transport
cellular response to starvation
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of sodium ion import across plasma membrane
negative regulation of receptor-mediated endocytosis involved in cholesterol transport
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