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Invitrogen
F4/80 Polyclonal Antibody
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图: 1 / 8
F4/80 Antibody (PA5-32399) in ICC/IF
Biotechnology and bioengineering 2020 -
1 Figure Transplantation of adipose tissue with hIL-4 PLG implants. (a) Transplantation of implants into eWAT fat pads; left-implants placed in each eWAT fat pad before folding fat pad over the implant and returning to abdominal cavity: right--implants in eWAT fat pads 2 weeks after transplantation. (b) Study design timeline. (c) Expression of hIL-4 in murine adipose tissue measured by qRT-PCR at 2 and 10 w... View More
产品信息
PA5-32399
应用
建议稀释比
已发表文章
产品规格
已发表种属
C. elegans,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from N-terminus of mouse F4/80 protein.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Heat-mediated antigen retrieval is recommended prior to staining, using a 1mM EDTA buffer, pH 8.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is human lung or mouse liver tissue.
靶标信息
F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
