Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
FAM175B Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
26868-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FAM175B Fusion Protein Ag22121 (69-415 aa encoded by BC008999)
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: YDYASKVNE ESLDRILKDR RKKVIGWYRF RRNTQQQMSY REQVLHKQLT RILGVPDLVF LLFSFISTAN NSTHALEYVL FRPNRRYNQR ISLAIPNLGN TSQQEYKVSS VPNTSQSYAK VIKEHGTDFF DKDGVMKDIR AIYQVYNALQ EKVQAVCADV EKSERVVESC QAEVNKLRRQ ITQRKNEKEQ ERRLQQAVLS RQMPSESLDP AFSPRMPSSG FAAEGRSTLG DAEASDPPPP YSDFHPNNQE STLSHSRMER SVFMPRPQAV GSSNYASTSA GLKYPGSGAD LPPPQRAAGD SGEDSDDSDY ENLIDPTEPS NSEYSHSKDS RPMAHPDEDP RNTQTSQI (69-415 aa encoded by BC008999 )
靶标信息
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Abraxas brother; abraxas brother 1; Abraxas brother protein 1; BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; Em:AC068896.4; family with sequence similarity 175, member B; Protein FAM175B
基因别名: AA589499; ABRAXAS2; ABRO1; AI853413; C430003P19Rik; FAM175B; KIAA0157
UniProt ID: (Human) Q15018, (Mouse) Q3TCJ1
Entrez Gene ID: (Human) 23172, (Mouse) 109359
