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Invitrogen
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Immunogen sequence: FLANCMNRHV HVKDDFVRSV SETQNIESQK IHSSRLSDIT SSNMQICGFK STVPHFTEEE KYQKLLSENK IRDEQPKHQP D
Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 50%.
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。