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Invitrogen
FAM49B Polyclonal Antibody
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产品信息
PA5-52647
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GNLLKVLTCT DLEQGPNFFL DFENAQPTES EKEIYNQVNV VLKDAEGILE DLQSYRGAGH EIREAIQHPA DEKLQEKAWG AVVPLVGKLK KFYEFSQRLE AALRGLLGAL TSTPYSPTQH LEREQALAKQ FAE
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
靶标信息
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CYFIP-related Rac1 interactor B; family with sequence similarity 49, member B; L1
基因别名: BM-009; CYRI; CYRIB; FAM49B; L1
UniProt ID: (Human) Q9NUQ9
Entrez Gene ID: (Human) 51571
