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Invitrogen
FDFT1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-52619
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PEEFYNLVRF RIGGKRKVMP KMDQDSLSSS LKTCYKYLNQ TSRSFAAVIQ ALDGEMRNAV CIFYLVLRAL DTLEDDMTIS VEKKVPLLHN FHSFLYQPDW RFMESKEKDR QVLEDFPTIS LEFRNLAEKY QTVIADICR
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 81%.
靶标信息
FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: farnesyl diphosphate:farnesyl diphosphate farnesyltransferase; FDFT1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; squalene synthetase; unnamed protein product
基因别名: DGPT; ERG9; SQS; SQSD; SS
UniProt ID: (Human) P37268
Entrez Gene ID: (Human) 2222
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