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Invitrogen
FGF4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79256
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human FGF4 (84-97aa RRLYCNVGIGFHLQ).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA Cell.
靶标信息
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGF; FGF4si; Fibroblast growth factor; fibroblast growth factor (put.); putative; fibroblast growth factor 7a; heparin secretory transforming protein 1; heparin-binding growth factor 1; heparin-binding growth factor 4; human stomach cancer, transforming factor from FGF-related oncogene; K-fibroblast growth factor; kaposi sarcoma oncogene; oncogene HST; transforming protein KS3; unnamed protein product
基因别名: FGF-4; Fgf7a; Fgfk; HBGF-4; HST; HST-1; Hst1; HSTF-1; HSTF1; K-FGF; KFGF; KS3; SRTD22
UniProt ID: (Human) P08620, (Mouse) P11403
Entrez Gene ID: (Human) 2249, (Mouse) 14175, (Rat) 116499
signal transduction
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
mesenchymal cell proliferation
neurogenesis
regulation of cell migration
positive regulation of MAPK cascade
chondroblast differentiation
positive regulation of ERK1 and ERK2 cascade
regulation of endothelial cell chemotaxis to fibroblast growth factor
cartilage condensation
positive regulation of protein phosphorylation
regulation of gene expression
positive regulation of gene expression
stem cell population maintenance
embryonic limb morphogenesis
embryonic hindlimb morphogenesis
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
cranial suture morphogenesis
apoptotic process involved in morphogenesis
cellular response to leukemia inhibitory factor
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