Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
FGF6 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 1
FGF6 Antibody (PA5-47306) in Neu
Neutralization of FGF6 in NR6R‚3T3 mouse fibroblast cell line. Samples were incubated in FGF6 polyclonal antibody (Product # PA5-47306). Recombinant Human FGF‚6 stimulates proliferation in the NR6R‚3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human FGF‚6 (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human FGF‚6 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 0.2-1 µg/mL in the presence of heparin (1 µg/mL).
产品信息
PA5-47306
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human FGF-6 Gly41-Ile208
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In Western blots, approximately 50% cross-reactivity with recombinant human (rh) FGF-4 is observed, less than 5% cross-reactivity with rhFGF-9 is observed, and less than 2% cross-reactivity with FGF-acidic, rhFGF-5, and rhFGF-7 is observed. In direct ELISAs, less than 1% cross-reactivity with rh beta -ECGF, recombinant mouse (rm) FGF-8b, and rmFGF-8c is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
FGF-6 is a secreted, heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4.4
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: FGF; FGF-6; Fibroblast growth factor; Fibroblast growth factor 6; HBGF-6; Heparin secretory-transforming protein 2; Heparin-binding growth factor 6; HST-2; HSTF-2
基因别名: FGF6; HBGF-6; HST2; HSTF2
UniProt ID: (Human) P10767
Entrez Gene ID: (Human) 2251
MAPK cascade
cartilage condensation
angiogenesis
signal transduction
cell-cell signaling
cell proliferation
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
myoblast differentiation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of cell division
