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Bethyl Laboratories
FKBP4/FKBP52 Polyclonal Antibody
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产品信息
A301-426A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1 and 50 of human FK506 binding protein 4.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Rabbit
靶标信息
FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP51; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD
基因别名: 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP4; FKBP51; FKBP52; FKBP59; FKPB52; HBI; Hsp56; p52; p59; PPIase
UniProt ID: (Human) Q02790, (Mouse) P30416
Entrez Gene ID: (Human) 2288, (Mouse) 14228
peptidyl-prolyl cis-trans isomerase activity
protein binding
ATP binding
GTP binding
FK506 binding
protein binding, bridging
heat shock protein binding
copper-dependent protein binding
glucocorticoid receptor binding
poly(A) RNA binding
tau protein binding
phosphoprotein binding
isomerase activity
chaperone
protein peptidyl-prolyl isomerization
protein folding
steroid hormone receptor complex assembly
copper ion transport
embryo implantation
negative regulation of neuron projection development
androgen receptor signaling pathway
prostate gland development
negative regulation of microtubule polymerization or depolymerization
negative regulation of microtubule polymerization
protein complex localization
male sex differentiation
chaperone-mediated protein folding
regulation of cellular response to heat
reproductive structure development
