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PA1-4167 detects the FLASH protein in Human, rat, and mouse samples.
PA1-4167 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~212 kDa protein representing FLASH in NIH3T3 cells.
The PA1-4167 immunogen is a synthetic peptide corresponding to residues A(19) S P L K N N D E G S L D(31) of mouse FLASH.
Maintain at 4°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze/thaw cycles.
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CASP8-associated protein 2; casp8ap2; FLICE-associated huge protein; FLJ11208; RP11-63K6.3
基因别名: AA387232; Casp8ap2; D4Ertd659e; FLASH; mKIAA1315
UniProt ID: (Mouse) B1AX74
Entrez Gene ID: (Mouse) 26885