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Proteintech
FLT3 Polyclonal Antibody
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产品信息
21049-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FLT3 Fusion Protein Ag15391 (27-376 aa encoded by BC036028)
偶联物
形式
Liquid
浓度
0.13 mg/mL
规格
19.5 µg
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NQDLPVIKC VLINHKNNDS SVGKSSSYPM VSESPEDLGC ALRPQSSGTV YEAAAVEVDV SASITLQVLV DAPGNISCLW VFKHSSLNCQ PHFDLQNRGV VSMVILKMTE TQAGEYLLFI QSEATNYTIL FTVSIRNTLL YTLRRPYFRK MENQDALVCI SESVPEPIVE WVLCDSQGES CKEESPAVVK KEEKVLHELF GTDIRCCARN ELGRECTRLF TIDLNQTPQT TLPQLFLKVG EPLWIRCKAV HVNHGFGLTW ELENKALEEG NYFEMSTYST NRTMIRILFA FVSSVARNDT GYYTCSSSKH PSQSALVTIV EKGFINATNS SEDYEIDQYE EFCFSVRFKA Y (27-376 aa encoded by BC036028)
靶标信息
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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