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Antibody detects endogenous levels of total FMN2.
FMN2, a novel formin homology protein of the cappuccino subfamily, is highly conserved between evolutionarily diverse vertebrates. FMN2 bears a high degree of similarity to formin-1 which is the founding member of formin homology proteins. FMN2 plays a crucial role in maintenance of the meiotic spindle. The protein is widely expressed in human fetal brain, adult whole brain, hypothalamus, retina, pancreatic islet and germinal-center B cells. Pathological role of the protein is identified in various tumors like parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma. FMN2 mutations are often a cause of unexplained infertility in women. The gene encoding for human FMN2 is localized in the chromosomal region 1q43.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: formin 2-like; Formin-2; RP11-90L13.1
基因别名: AU024104; FMN2
UniProt ID: (Human) Q9NZ56, (Mouse) Q9JL04
Entrez Gene ID: (Human) 56776, (Mouse) 54418, (Rat) 100360457