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Proteintech
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Immunogen sequence: STDGHQPLF PKPIYSYSIL IFMALKNSKT GSLPVSEIYN FMTEHFPYFK TAPDGWKNSV RHNLSLNKCF EKVENKSGSS SRKGCLWALN PAKIDKMQEE LQKWKRKDPI AVRKSMAKPE ELDSLIGDKR EKLGSPLLGC PPPGLSGSGP IRPLAPPAGL SPPLHSLHPA PGPIPGKNPL QDLLMGHTPS CYGQTYLHLS PGLAPPGPPQ PLFPQPDGHL ELRAQPGTPQ DSPLPAHTPP SHSAKLLAEP SPARTMHDTL LPDGDLGTDL DAINPSLTDF DFQGNLWEQL KDDSLALDPL VLVTSSPTSS SMPPPQPPPH CFPPGPCLTE TGSGAGDLAA PGSGGSGALG DLHLTTLYSA FMELEPTPPT APAGPSVYLS PSSKPVALA (261-648 aa encoded by BC146539)
FOXN1 is a 648 amino acid protein belonging to the winged helix/forkhead family It contains 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. FOXN1 is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicles and nail apparatus and its defects lead to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Forkhead box protein N1; JTK1; Rowett nude; winged helix nude; winged-helix nude; Winged-helix transcription factor nude
基因别名: FKHL20; FOXN1; RONU; WHN
UniProt ID: (Human) O15353
Entrez Gene ID: (Human) 8456