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Invitrogen
FOXO3A Recombinant Rabbit Monoclonal Antibody (5H17L19)
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图: 1 / 3
FOXO3A Antibody (701847) in ICC/IF
For immunofluorescence analysis, serum starved (16 hours) SH-SY5Y cells were fixed and permeabilized for detection of endogenous Foxo3A using Anti- Foxo3A Recombinant Rabbit Monoclonal Antibody (Product # 701847, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Foxo3A protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mou... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
701847
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5H17L19
抗原
Peptides corresponding to Human FOXO3 (aa 298-312, 634-646)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Sheep, Pig and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: forkhead box O3A; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO3A-; unnamed protein product
基因别名: AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
UniProt ID: (Human) O43524
Entrez Gene ID: (Human) 2309
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
mitochondrial RNA polymerase binding promoter specificity activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from mitochondrial promoter
regulation of translation
response to xenobiotic stimulus
positive regulation of autophagy
positive regulation of muscle atrophy
negative regulation of cell migration
response to nutrient levels
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
cellular response to glucose starvation
response to starvation
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of regulatory T cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to fatty acid
cellular response to glucose stimulus
cellular response to corticosterone stimulus
response to dexamethasone
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
response to water-immersion restraint stress
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