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QED Bioscience
FPR1/2 Monoclonal Antibody (NFPR1)
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产品信息
30107-100UG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
NFPR1
抗原
His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells.
偶联物
形式
Liquid
浓度
0.5-1.0 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N- formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells. FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Diamond-Blackfan Anemia 2 and Prion Disease. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: fMet-Leu-Phe receptor; fMLP receptor; FMLP-R-I; FMLP-related receptor I; Formyl peptide receptor-like 1; FPR; HM63; Lipoxin A4 receptor; lipoxin A4 receptor (formyl peptide receptor related); LXA4 receptor; N-formyl peptide receptor; N-formyl peptide receptor 2; N-formylpeptide chemoattractant receptor; RFP
基因别名: ALXR; FMLP; FMLP-R-II; FMLPX; FPR; FPR1; FPR2; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
UniProt ID: (Human) P21462, (Human) P25090
Entrez Gene ID: (Human) 2357, (Human) 2358
activation of MAPK activity
movement of cell or subcellular component
chemotaxis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
nitric oxide mediated signal transduction
inflammatory response
cell adhesion
