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Invitrogen
FRY Polyclonal Antibody
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FRY Antibody (PA5-143851) in IHC (P)
Immunohistochemistry analysis of FRY in paraffin-embedded section of human liver cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with FRY Polyclonal antibody (Product # PA5-143851) using a dilution of 5 μg/mL overnight at 4°C. DyLight®550 Conjugated Goat Anti-Rabbit Ig... View More
产品信息
PA5-143851
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human FRY recombinant protein (Position: E11-L3013).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human RT4 whole cell, human Caco-2 whole cell, rat brain tissue, rat lung tissue, mouse brain tissue, mouse lung tissue. IHC: human colorectal adenocarcinoma tissue, human liver cancer tissue, human lung cancer tissue, human ovarian cancer tissue, human penis squamous cell carcinoma tissue. Flow: SiHa cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The FRY gene encodes a protein known as furry homolog (FRY), a gene that is highly conserved across species and plays vital roles in cell division and differentiation. FRY is involved in the regulation of mitotic spindle orientation and cellular polarity, crucial for proper cell division and tissue organization. It is found within various tissues and has implications in neurodevelopment and cancer biology, where it influences cell structural properties and signaling pathways. Alterations in FRY expression or mutations can disrupt normal cell function, leading to aberrant cellular morphogenesis and developmental defects. In cancer studies, FRY is associated with tumor suppression, where loss of function contributes to uncontrolled cell proliferation. This gene interacts with other cellular components, such as the cytoskeleton and signaling proteins, orchestrating complex cellular processes essential for maintaining homeostasis and development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: furry homolog; Protein furry homolog; WUGSC:H_2G3A.1
基因别名: 13CDNA73; 214K23.2; 9330186A19Rik; AF346502; AI462658; bA207N4.2; bA37E23.1; C13orf14; C87180; CG003; D930046M03; FRY; Kiaa4143; mKIAA4143; RGD1307034
UniProt ID: (Human) Q5TBA9, (Mouse) E9Q8I9
Entrez Gene ID: (Human) 10129, (Mouse) 320365, (Rat) 304244
