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FUS Antibody (MA3-089) in ICC/IF
Immunofluorescence of FUS was performed using HeLa wild-type and FUS KO cells that were transfected with a green or a far red fluorescent dye, respectively. Post-transfection, WT and KO cells were mixed and plated to a 1:1 ratio on coverslips as a mosaic and incubated for 24 hrs. Cells were fixed in 4% PFA (in PBS) for 15 min; cells were permeabilized with 0.1% Triton X-100 for 10 min at RT and blocked with PBS with 5% BSA, 5% goat serum, and 0.01% Triton X-100 for 30 min. Cells were stained with the FUS monoclonal antibody (Product # MA3-... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA3-089
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1FU-1D2
抗原
Synthetic peptide (GPRDQGSRHDSEQDNSDC) coupled to ovalbumin. From aa 266 to aa 283 of FUS
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA3-089 detects AID from human samples
MA3-089 has been successfully used in Western blot.
The MA3-089 immunogen is the synthetic peptide coupled to ovalalbumin, aa 266 to 283. MA3-089 detects FUS/TLS (~70kDa) in human samples.
靶标信息
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 75 kDa DNA-pairing protein; FUS; fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; nuclear RNA-binding protein; oncogene FUS; oncogene TLS; translocated in liposarcoma protein; unnamed protein product
基因别名: ALS6; altFUS; ETM4; FUS1; HNRNPP2; POMP75; TLS
UniProt ID: (Human) P35637
Entrez Gene ID: (Human) 2521
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
RNA splicing
regulation of RNA splicing
positive regulation of transcription, DNA-templated
mRNA stabilization
protein homooligomerization
membraneless organelle assembly
positive regulation of double-strand break repair via homologous recombination
amyloid fibril formation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
