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FUSIP1 Polyclonal Antibody
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FUSIP1 Antibody (BS-13229R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat testis tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-FUSIP1 Polyclonal Antibody, Unconjugated (bs-13229R) at 1:400 overnight at 4°C, followed by a conjugated secondary and ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
BS-13229R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human FUSIP1, amino acids 151-250.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
SRSF10 (Serine and Arginine Rich Splicing Factor 10) is a member of the SR family of RNA-binding proteins that regulates alternative pre-mRNA splicing. It contains an RNA recognition motif (RRM) and a serine/arginine-rich (RS) domain that mediates RNA binding and protein-protein interactions within the spliceosome. SRSF10 functions as a context-dependent splicing regulator, capable of promoting or repressing exon inclusion depending on cellular conditions. Notably, it undergoes phosphorylation-dependent regulation, and during cellular stress or mitosis it can shift from an activator to a repressor of splicing. SRSF10 has been implicated in cell cycle control, apoptosis, metabolic regulation, and cancer-associated splicing alterations. Formerly known as FUSIP1 (FUS-interacting protein 1), SRSF10 is widely studied for its role in dynamic and stress-responsive RNA processing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40 kDa SR-repressor protein; contains RNP1 and RNP2 motifs; RS domain; contains Ser-Arg (SR) repeats; FUS interacting protein (serine-arginine rich) 1; FUS interacting protein (serine/arginine-rich) 1; Fus-associated protein with serine-arginine repeats; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; neural-salient serine/arginine-rich protein; neural-salient SR protein; neural-specific SR protein; protein phosphatase 1, regulatory subunit 149; serine-arginine repressor protein (40 kDa); serine/arginine-rich splicing factor 13A; splicing factor; splicing factor SRp38; splicing factor, arginine/serine-rich 13; splicing factor, arginine/serine-rich 13A; SR protein; SR splicing factor 10; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein; unnamed protein product
基因别名: FUSIP1; FUSIP2; NSSR; NSSR1; NSSR2; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; Srsf13a; TASR; TASR1; TASR2
UniProt ID: (Human) O75494, (Mouse) Q9R0U0
Entrez Gene ID: (Human) 10772, (Mouse) 14105, (Rat) 362630
RNA splicing, via transesterification reactions
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
regulation of transcription, DNA-templated
mRNA splice site selection
cytosolic transport
regulation of mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
biological_process
spliceosomal tri-snRNP complex assembly
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