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Abnova
FUT8 Polyclonal Antibody, MaxPab™
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产品信息
H00002530-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FUT8 (NP_835367.1, 1 a.a. approximately 575 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGK DHEILRRRIE NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK
靶标信息
Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465
基因别名: FUT8
UniProt ID: (Human) Q9BYC5
Entrez Gene ID: (Human) 2530
in utero embryonic development
protein N-linked glycosylation
N-glycan processing
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
respiratory gaseous exchange
oligosaccharide biosynthetic process
regulation of gene expression
cell migration
protein N-linked glycosylation via asparagine
protein glycosylation in Golgi
N-glycan fucosylation
L-fucose catabolic process
receptor metabolic process
GDP-L-fucose metabolic process
regulation of cellular response to oxidative stress
