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Agrisera
FtsH3+FtsH10/ATP-dependent zinc metalloprotease FtsH3+FtsH10 (mitochondrial) Polyclonal Antibody
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FtsH3+FtsH10/ATP-dependent zinc metalloprotease FtsH3+FtsH10 (mitochondrial) Antibody (AS07-204) in WB
Total protein from Arabidopsis thaliana mitochondria (20 µg) were separated on 10% acrilamide gel and electrophoresis prepared according to Schägger and von Jagov (Anl. Biochem., 1987,166:368-379). After running the gel, proteins were transferred to nitrocellulose membrane using wet transfer (0.22% CAPS, p H 11). Transfer was checked by Ponceau S staining. Blot was destained by several quick washings in dis... View More
产品信息
AS07-204
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from sequences of Arabidopsis thaliana FtsH3 and FtsH10 with localization to mitochondria.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
200 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 100 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
FtsH3 and FtsH10 encode closely related, nuclear-encoded AAA+ zinc metalloproteases of the FtsH/M41 family that localize to plant mitochondria, where they are embedded in the inner mitochondrial membrane and assemble into high-molecular-weight m-AAA protease complexes. Each protein is synthesized with an N-terminal mitochondrial targeting region followed by membrane-anchoring segments and a large catalytic moiety containing a conserved AAA ATPase (unfoldase/chaperone) domain coupled to a HEXXH zinc-dependent protease domain that together drive ATP-dependent extraction, unfolding, and proteolysis of membrane-embedded substrates. Functionally, the FtsH3/FtsH10 m-AAA system contributes to mitochondrial proteostasis by supporting quality control and remodeling of oxidative phosphorylation components; genetic and biochemical evidence indicates FtsH3 activity influences respiratory Complex I abundance by promoting complex disassembly/turnover, and FtsH3 and FtsH10 have been implicated in mitochondrial translation-related protein processing, consistent with a broader role in maintaining inner-membrane protein homeostasis under basal and stress conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT1G07510; AT2G29080; F22G5.10; F22G5_10; FTSH10; FTSH3; T9I4.16; T9I4_16
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