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Antibodies Inc
GABA-A-R-Gamma2L Monoclonal Antibody (N452/69)
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产品信息
75-442
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N452/69
抗原
Fusion protein amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (accession number P18507-2) produced recombinantly in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
GABA-A-R-Gamma2L refers to the long splice variant of the gamma2 subunit of the GABA-A receptor, which is a major inhibitory neurotransmitter receptor in the central nervous system. The gamma2 subunit is critical for the receptor's proper assembly, trafficking, and synaptic localization, and it influences the receptor's pharmacological properties, including its sensitivity to benzodiazepines. Mutations or alterations in the gamma2 subunit, including the gamma2L variant, can affect inhibitory neurotransmission and are associated with neurological disorders such as epilepsy and anxiety.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit gamma-2; GABA(A) receptor, gamma 2; GABAAR subunit gamma-2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2
基因别名: CAE2; ECA2; GABAA-R; Gabrg-2; GABRG2; gamma2; GEFSP3
UniProt ID: (Human) F5HB82, (Mouse) P22723, (Rat) P18508
Entrez Gene ID: (Human) 2566, (Mouse) 14406, (Rat) 29709
transport
gamma-aminobutyric acid signaling pathway
post-embryonic development
adult behavior
ion transmembrane transport
synaptic transmission, GABAergic
cellular response to histamine
chloride transmembrane transport
ion transport
chloride transport
signal transduction
chemical synaptic transmission
