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Antibodies Inc
GABA-A-R-Gamma2L/S Monoclonal Antibody (N452/73), FL594
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产品信息
75-484-FL594
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N452/73
抗原
Fusion protein amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (accession number P18507-2) produced recombinantly in E. Coli.
偶联物
激发/发射光谱
594/615 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
GABA-A-R-Gamma2L and GABA-A-R-Gamma2S are two splice variants of the gamma2 subunit of the GABA-A receptor, which is crucial for mediating inhibitory neurotransmission in the central nervous system. The gamma2L (long) variant includes an extra eight amino acids compared to the gamma2S (short) variant, potentially influencing the receptor's synaptic localization and pharmacological properties. Both variants are essential for the receptor's proper function, and their dysregulation can be associated with neurological disorders such as epilepsy and anxiety.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit gamma-2; GABA(A) receptor, gamma 2; GABAAR subunit gamma-2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2
基因别名: CAE2; ECA2; GABAA-R; Gabrg-2; GABRG2; gamma2; GEFSP3
UniProt ID: (Human) F5HB82, (Mouse) P22723, (Rat) P18508
Entrez Gene ID: (Human) 2566, (Mouse) 14406, (Rat) 29709
transport
gamma-aminobutyric acid signaling pathway
post-embryonic development
adult behavior
ion transmembrane transport
synaptic transmission, GABAergic
cellular response to histamine
chloride transmembrane transport
ion transport
chloride transport
signal transduction
chemical synaptic transmission
