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Proteintech
GADD34 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
10449-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Hamster,
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GADD34 Fusion Protein Ag0578 (307-572 aa encoded by BC003067)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.26 mg/mL
规格
39 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Molecular weight of GADD34 is 100 kDa confirmed in GADD34 KO mice, and Proteintech's GADD34 antibody 10449-1-AP primarily recognize the 100 kDa band.
Immunogen sequence: SDEEEGEVK ALGAAEKDGE AECPPCIPPP SAFLKAWVYW PGEDTEEEED EEEDEDSDSG SDEEEGEAEA SSSTPATGVF LKSWVYQPGE DTEEEEDEDS DTGSAEDERE AETSASTPPA SAFLKAWVYR PGEDTEEEED EDVDSEDKED DSEAALGEAE SDPHPSHPDQ RAHFRGWGYR PGKETEEEEA AEDWGEAEPC PFRVAIYVPG EKPPPPWAPP RLPLRLQRRL KRPETPTHDP DPETPLKARK VRFSEKVTVH FLAVWAG (307-572 aa encoded by BC003067 )
靶标信息
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116; myeloid differentiation primary response protein MyD116 homolog; PPP1R15A; PR15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; unnamed protein product
基因别名: 9630030H21; GADD34; Myd116
UniProt ID: (Human) O75807, (Mouse) P17564
Entrez Gene ID: (Human) 23645, (Mouse) 17872
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
regulation of translational initiation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of peptidyl-threonine phosphorylation
negative regulation of protein processing
endoplasmic reticulum unfolded protein response
positive regulation of translational initiation in response to stress
response to endoplasmic reticulum stress
regulation of translation in response to endoplasmic reticulum stress
positive regulation of apoptotic process
regulation of translational initiation in response to stress
regulation of angiogenesis
positive regulation of transcription from RNA polymerase I promoter
regulation of protein metabolic process
protein localization to endoplasmic reticulum
positive regulation of signal transduction by p53 class mediator
apoptotic process
cellular response to DNA damage stimulus
negative regulation by host of viral genome replication
regulation of cell cycle
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of PERK-mediated unfolded protein response
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