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Proteintech
GALE Polyclonal Antibody
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产品信息
14414-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GALE Fusion Protein Ag5756 (1-348 aa encoded by BC050685)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAEKVLVTG GAGYIGSHTV LELLEAGYLP VVIDNFHNAF RGGGSLPESL RRVQELTGRS VEFEEMDILD QGALQRLFKK YSFMAVIHFA GLKAVGESVQ KPLDYYRVNL TGTIQLLEIM KAHGVKNLVF SSSATVYGNP QYLPLDEAHP TGGCTNPYGK SKFFIEEMIR DLCQADKTWN AVLLRYFNPT GAHASGCIGE DPQGIPNNLM PYVSQVAIGR REALNVFGND YDTEDGTGVR DYIHVVDLAK GHIAALRKLK EQCGCRIYNL GTGTGYSVLQ MVQAMEKASG KKIPYKVVAR REGDVAACYA NPSLAQEELG WTAALGLDRM CEDLWRWQKQ NPSGFGTQA (1-348 aa encoded by BC050685 )
靶标信息
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: galactose-4-epimerase, UDP-; Galactowaldenase; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-glucose 4-epimerase; UDP-N-acetylgalactosamine 4-epimerase; UDP-N-acetylglucosamine 4-epimerase
基因别名: 2310002A12Rik; AI323962; GALE; SDR1E1
UniProt ID: (Human) Q14376, (Mouse) Q8R059
Entrez Gene ID: (Human) 2582, (Mouse) 74246
