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GATA1 Monoclonal Antibody (5E2A8)

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GATA1 Monoclonal Antibody (5E2A8)

产品信息

60011-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

1:800
-

免疫细胞化学 (ICC/IF)

-
查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells
-

免疫沉淀 (IP)

Assay-dependent
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Pig, Rat

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

5E2A8

抗原

GATA1 Fusion Protein Ag1350 (1-316 aa encoded by BC009797)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MEFPGLGSL GTSEPLPQFV DPALVSSTPE SGVFFPSGPE GLDAAASSTA PSTATAAAAA LAYYRDAEAY RHSPVFQVYP LLNCMEGIPG GSPYAGWAYG KTGLYPASTV CPTREDSPPQ AVEDLDGKGS TSFLETLKTE RLSPDLLTLG PALPSSLPVP NSAYGGPDFS STFFSPTGSP LNSAAYSSPK LRGTLPLPPC EARECVNCGA TATPLWRRDR TGHYLCNACG LYHKMNGQNR PLIRPKKRLI VSKRAGTQCT NCQTTTTTLW RRNASGDPVC NACGLYYKLH HQHYCGGSAQ LMRAQSMASR GGVVSFS (1-316 aa encoded by BC009797)

靶标信息

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Eryf1; Erythroid transcription factor; erythroid transcription factor 1; GATA 1 protein; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA-binding protein 1; GATA-binding protein 1 (globin transcription factor 1); GF-1; globin transcription factor 1; HGNC:4170; NF-E1 DNA-binding protein; nuclear factor, erythroid 1; transcription factor GATA1

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基因别名: ERYF1; GATA-1; GATA1; GF-1; GF1; NF-E1; NFE1; XLANP; XLTDA; XLTT

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UniProt ID: (Human) P15976, (Mouse) P17679, (Rat) P43429

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Entrez Gene ID: (Pig) 100620659, (Human) 2623, (Mouse) 14460, (Rat) 25172

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功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding DNA binding, bending chromatin DNA binding sequence-specific DNA binding C2H2 zinc finger domain binding RNA polymerase II transcription factor activity, sequence-specific DNA binding chromatin binding metal ion binding DNA-binding transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development transcription from RNA polymerase II promoter cell-cell signaling heart development blood coagulation negative regulation of cell proliferation male gonad development organ morphogenesis tissue development regulation of glycoprotein biosynthetic process regulation of definitive erythrocyte differentiation regulation of primitive erythrocyte differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation basophil differentiation eosinophil differentiation negative regulation of bone mineralization positive regulation of osteoblast proliferation embryonic hemopoiesis eosinophil fate commitment negative regulation of apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development erythrocyte development homeostasis of number of cells within a tissue positive regulation of peptidyl-tyrosine phosphorylation platelet aggregation transcriptional activation by promoter-enhancer looping dendritic cell differentiation cellular response to thyroid hormone stimulus negative regulation of transcription regulatory region DNA binding negative regulation of extrinsic apoptotic signaling pathway in absence of ligand transcription, DNA-templated regulation of transcription, DNA-templated myeloid cell differentiation cell development organ regeneration Sertoli cell development cellular response to lipopolysaccharide cellular response to cAMP cellular response to follicle-stimulating hormone stimulus
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