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Proteintech
GATA2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
11103-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GATA2 Fusion Protein Ag1557 (168-467 aa encoded by BC018988)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.36 mg/mL
规格
54 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SHLFGFPPT PPKEVSPDPS TTGAASPASS SAGGSAARGE DKDGVKYQVS LTESMKMESG SPLRPGLATM GTQPATHHPI PTYPSYVPAA AHDYSSGLFH PGGFLGGPAS SFTPKQRSKA RSCSEGRECV NCGATATPLW RRDGTGHYLC NACGLYHKMN GQNRPLIKPK RRLTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG (168-467 aa encoded by BC018988)
靶标信息
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ45948; GATA-bindning protein 2; MGC2306; unnamed protein product
基因别名: DCML; Gata-2; IMD21; MONOMAC; NFE1B
UniProt ID: (Human) P23769, (Rat) Q924Y4, (Mouse) O09100
Entrez Gene ID: (Human) 2624, (Rat) 25159, (Mouse) 14461
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
C2H2 zinc finger domain binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
cell fate determination
neuron migration
embryonic placenta development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cytosolic calcium ion concentration
positive regulation of gene expression
negative regulation of gene expression
regulation of primitive erythrocyte differentiation
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
cell differentiation
neuron differentiation
response to lipid
somatic stem cell population maintenance
eosinophil fate commitment
inner ear morphogenesis
positive regulation of mast cell degranulation
positive regulation of blood vessel endothelial cell migration
cell fate commitment
fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
cell maturation
animal organ development
neuron fate commitment
homeostasis of number of cells within a tissue
positive regulation of phagocytosis
regulation of developmental process
positive regulation of phagocytosis, engulfment
definitive hemopoiesis
semicircular canal development
vascular wound healing
positive regulation of cell migration involved in sprouting angiogenesis
cochlea development
GABAergic neuron differentiation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
negative regulation of endothelial cell apoptotic process
regulation of forebrain neuron differentiation
anatomical structure morphogenesis
positive regulation of transcription, DNA-templated
system development
regulation of multicellular organismal process
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