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Invitrogen
GATAD2A Polyclonal Antibody
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Product Details
PA5-55065
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GATAD2A. Recombinant protein control fragment (Product #RP-89394).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LERDPTEDDV ESKKIKMERG LLASDLNTDG DMRVTPEPGA GPTQGLLRAT EATAMAMGRG EGLVGDGPVD MRTSHSDMKS ERRPPSPDVI VLSDNEQPSS PRVNGLTTVA LKETSTE
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 79%.
Target Information
GATAD2A is a gene encoding a protein that functions as a subunit of the nucleosome remodeling and deacetylase (NuRD) complex, which plays a crucial role in chromatin remodeling and gene expression regulation. Located on the human chromosome, GATAD2A contains proline-rich PPPL theta motifs that facilitate interactions with MYND domains in proteins such as ZMYND8, distinguishing it from its paralog GATAD2B. This gene is important for various cellular processes, particularly during neural development, where it participates in modulating chromatin structure through histone deacetylation and ATP-dependent remodelings, like those mediated by NuRD. Moreover, GATAD2A has been implicated in certain neurodevelopmental disorders, suggesting its distinct functional roles in cellular contexts. Additionally, research has identified circular RNA variants of GATAD2A, which have been shown to influence viral replication, indicating its broader impact on cellular function beyond chromatin modification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GATA zinc finger domain-containing protein 2A; Hp66alpha; MGC29315; MGC36975; p66a; Transcriptional repressor p66-alpha
Gene Aliases: GATAD2A; p66alpha
UniProt ID: (Human) Q86YP4
Entrez Gene ID: (Human) 54815
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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