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Abnova
GBA Monoclonal Antibody (200)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00002629-M01J
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
200
抗原
GBA (NP_000148.2, 146 a.a. approximately 235 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: SYFSEEGIGY NIIRVPMASC DFSIRTYTYA DTPDDFQLHN FSLPEEDTKL KIPLIHRALQ LAQRPVSLLA SPWTSPTWLK TNGAVNGKGS
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acid beta-glucosidase; alglucerase; beta-GC; beta-glucocerebrosidase; beta-glucosylceramidase 1; cholesterol glucosyltransferase; cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucocerebrosidase; glucocerebrosidase precursor (5' end put.); putative; glucosidase, beta, acid; glucosylceramidase-like protein; imiglucerase; lysosomal acid GCase; lysosomal cholesterol glycosyltransferase; lysosomal galactosylceramidase; lysosomal glucocerebrosidase; lysosomal glycosylceramidase; SGTase; unnamed protein product
基因别名: GBA; GCB; GLUC
UniProt ID: (Human) P04062
Entrez Gene ID: (Human) 2629
sphingolipid metabolic process
glucosylceramide catabolic process
autophagy
mitochondrion organization
lysosome organization
cholesterol metabolic process
glycolipid biosynthetic process
cellular response to starvation
response to pH
regulation of macroautophagy
glycolipid catabolic process
termination of signal transduction
protein catabolic process
neuron projection development
regulation of TOR signaling
negative regulation of interleukin-6 production
response to testosterone
regulation of protein catabolic process
regulation of membrane potential
negative regulation of MAPK cascade
response to estrogen
sphingosine biosynthetic process
ceramide biosynthetic process
negative regulation of inflammatory response
establishment of skin barrier
cellular response to tumor necrosis factor
response to dexamethasone
response to thyroid hormone
skin epidermis development
beta-glucoside catabolic process
positive regulation of neuronal action potential
lysosomal protein catabolic process
regulation of lysosomal protein catabolic process
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