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Invitrogen
GCLC Polyclonal Antibody
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GCLC Antibody (PA5-16581) in ICC/IF
Immunofluorescence analysis of Gamma-Glutamyl cysteine Synthetase/Glutamate-cysteine was performed using70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with GCLC Rabbit Polyclonal Antibody (Product # PA5-16581) at 2µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary ... View More
产品信息
PA5-16581
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide derived from corresponding to aa 295-313 of rat GCLC (heavy subunit of GCS)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
PA5-16581 targets Gamma-Glutamyl cysteine Synthetase/Glutamate-cysteine Ligase in IP and WB applications and shows reactivity with Bovine, Human, mouse, Non-human primate, and Rat samples.
The PA5-16581 immunogen is a synthetic peptide derived from corresponding to aa 295-313 of rat GCLC (heavy subunit of GCS).
靶标信息
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
