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Invitrogen
GCN1L1 Polyclonal Antibody
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产品信息
PA5-54043
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human GCN1L1
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: ALKEKLGTPD EQLEMANCQA VILSVEDDTG HRIIIEDLLE ATRSPEVGMR QAAAIILNIY CSRSKADYTS HLRSLVSGLI RLFNDSSPVV LEESWDALNA ITKKLDAGNQ LALIEELHKE IRLIGNESKG EHVPGFC
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
靶标信息
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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