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Invitrogen
GHRHR Polyclonal Antibody
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产品信息
PA3-117
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, KLH conjugated, corresponding to residues R(403) T R A K W T T P S R S A A K V L T S M(422) of human GHRH-R.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA3-117 detects GHRH-R in human samples.
PA3-117 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry procedures. By Western blot, this antibody detects an ~40 kDa protein representing GHRH-R in human samples. In immunohistochemistry, GHRH-R immunoreactivity is predominantly localized at the plasma membrane.
The PA3-117 immunizing peptide corresponds to amino acid residues 403-422 from human GHRH-R.
靶标信息
Growth Hormone Releasing Hormone (GHRH) is a member of a family of peptide hormones that also includes VIP (vasoactive intestinal polypeptide) and PACAP (pituitary adenylate cyclase-activating polypeptide). It is a hypothalamic peptide that binds to G-protein coupled receptors to stimulate secretion and synthesis of growth hormone (GH). GHRH receptor proteins have been identified on the plasma membrane of primary human tumor cells, and are thought to be involved in the growth of a variety of cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GHRH receptor; Ghrh-r; GHRHRpsv; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing hormone receptor
基因别名: GHRFR; GHRHR; GRFR; IGHD1B
UniProt ID: (Human) Q02643
Entrez Gene ID: (Human) 2692
cell surface receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
lactation
positive regulation of cell proliferation
determination of adult lifespan
cAMP-mediated signaling
water homeostasis
growth hormone secretion
positive regulation of cAMP biosynthetic process
response to insulin
cellular response to insulin stimulus
regulation of intracellular steroid hormone receptor signaling pathway
positive regulation of multicellular organism growth
hormone metabolic process
positive regulation of insulin-like growth factor receptor signaling pathway
response to estrogen
positive regulation of circadian sleep/wake cycle, non-REM sleep
cell maturation
multicellular organismal reproductive process
regulation of protein metabolic process
response to glucocorticoid
positive regulation of growth hormone secretion
somatotropin secreting cell development
cellular response to glucose stimulus
