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Invitrogen
GNAI1/GNAI2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-12708
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptides corresponding to residues 345-354 of Gi 1 and 346-355 of Gi 2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
0.08% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control for this product is IMR-5 cells or brain lysate.
靶标信息
The G protein family of signal transducers includes the alpha, beta, gamma subunits and the effector which are most clearly distinguished by their different alpha chains. The family also includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein of unknown function that is abundantly expressed in brain; and transducin 1 and 2, proteins involved in retinal phototransduction. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane-bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G protein; Gi1 protein alpha subunit; GNAI2; GTP-binding protein; GTP-binding protein (G-alpha-i2); GTP-binding regulatory protein Gi alpha-2 chain; guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein alpha subunit; guanine nucleotide-binding protein alpha-i subunit; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit; guanine nucleotide-binding regulatory protein alpha-inhibitory subunit; heterotrimeric guanine nucleotide-binding protein 1B; heterotrimeric guanine nucleotide-binding protein 1C; inhibitory G protein of adenylate cyclase, alpha chain; p-alpha-h subunit; sGi2; unnamed protein product
基因别名: BPGTPB; Galphai2; Gi; Gia; Gialpha1; GIP; Gnai-1; Gnai-2; GNAI2B; H_LUCA15.1; H_LUCA16.1; HG1B; HG1C; NEDHISB
UniProt ID: (Bovine) P63097, (Human) P63096, (Human) P04899, (Mouse) B2RSH2, (Rat) P10824, (Rat) P04897, (Mouse) P08752
Entrez Gene ID: (Bovine) 281790, (Human) 2770, (Human) 2771, (Bovine) 281791, (Mouse) 14677, (Rat) 25686, (Rat) 81664, (Mouse) 14678
magnesium ion binding
G-protein coupled receptor binding
GTPase activity
protein binding
GTP binding
GDP binding
obsolete small monomeric GTPase activity
adenylate cyclase inhibitor activity
guanyl nucleotide binding
G-protein beta/gamma-subunit complex binding
D2 dopamine receptor binding
G-protein coupled serotonin receptor binding
adenylate cyclase regulator activity
GTPase activating protein binding
heterotrimeric G-protein
cell cycle
G-protein coupled receptor signaling pathway
regulation of cAMP-mediated signaling
cell division
regulation of mitotic spindle organization
cellular response to forskolin
positive regulation of protein localization to cell cortex
establishment of mitotic spindle orientation
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
neuropeptide signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
response to prostaglandin E
mast cell degranulation
response to peptide hormone
positive regulation of cholesterol biosynthetic process
chemokine-mediated signaling pathway
T cell migration
positive regulation of relaxation of smooth muscle
regulation of eating behavior
angiogenesis
adenosine receptor signaling pathway
negative regulation of adenylate cyclase activity
gamma-aminobutyric acid signaling pathway
response to nutrient
positive regulation of cell proliferation
positive regulation of cell migration
positive regulation of superoxide anion generation
positive regulation of urine volume
negative regulation of calcium ion-dependent exocytosis
modulation of synaptic transmission
negative regulation of synaptic transmission
regulation of calcium ion transport
positive regulation of ERK1 and ERK2 cascade
negative regulation of adrenergic receptor signaling pathway
positive regulation of vascular smooth muscle cell proliferation
positive regulation of neural precursor cell proliferation
negative regulation of apoptotic signaling pathway
neurotransmitter receptor localization to postsynaptic specialization membrane
G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
cell proliferation
positive regulation of NAD(P)H oxidase activity
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