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Proteintech
GNAO1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
12635-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GNAO1 Fusion Protein Ag3330 (1-302 aa encoded by BC030027)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.22 mg/mL
规格
33 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MKIIHEDGF SGEDVKQYKP VVYSNTIQSL AAIVRAMDTL GIEYGDKERK ADAKMVCDVV SRMEDTEPFS AELLSAMMRL WGDSGIQECF NRSREYQLND SAKYYLDSLD RIGAADYQPT EQDILRTRVK TTGIVETHFT FKNLHFRLFD VGGQRSERKK WIHCFEDVTA IIFCVALSGY DQVLHEDETT NRMHESLMLF DSICNNKFFI DTSIILFLNK KDLFGEKIKK SPLTICFPEY TGPNTYEDAA AYIQAQFESK NRSPNKEIYC HMTCATDTNN IQVVFDAVTD IIIANNLRGC GLY (1-302 aa encoded by BC030027)
靶标信息
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686O0962; G alpha o; G protein; GNAO 1; Go alpha; GO2-q chimeric G-protein; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2; heterotrimeric guanine nucleotide-binding protein 1G; unnamed protein product
基因别名: alphaO; AW050213; DEE17; EIEE17; G-ALPHA-o; Galphao; Gna0; GNAO; GNAO1; HG1G; NEDIM; RATBPGTPC
UniProt ID: (Rat) P59215, (Mouse) P18872
Entrez Gene ID: (Human) 2775, (Rat) 50664, (Mouse) 14681
GTPase activity
obsolete small monomeric GTPase activity
protein binding
GTP binding
guanyl nucleotide binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
mu-type opioid receptor binding
corticotropin-releasing hormone receptor 1 binding
signal transducer activity
GDP binding
protein complex binding
GTPase activating protein binding
metal ion binding
nucleotide binding
heterotrimeric G-protein
muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
dopamine receptor signaling pathway
negative regulation of insulin secretion
negative regulation of neurotransmitter secretion
postsynaptic modulation of chemical synaptic transmission
aging
locomotory behavior
regulation of heart contraction
metabolic process
cellular process
response to organonitrogen compound
response to organic cyclic compound
forebrain development
neuron projection development
response to cytokine
response to drug
response to hydrogen peroxide
response to morphine
positive regulation of GTPase activity
negative regulation of calcium ion transport
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