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Invitrogen
GPR120 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-50973
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from the Internal region of human GPR120.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
GPR120 Polyclonal Antibody detects endogenous levels of GPR120 protein.
靶标信息
An EST for GPR120 has been isolated from a human colon cancer library. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Free fatty acid receptor 4; G protein-coupled receptor 120; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; G-protein-coupled receptor GT01; GPCR120; Omega-3 fatty acid receptor 1
基因别名: AI552415; FFAR4; GPR120; GPR129; GT01; KPG_013; O3FAR1; PGR4
UniProt ID: (Mouse) Q7TMA4, (Rat) Q2AC31
Entrez Gene ID: (Mouse) 107221, (Rat) 294075
signal transduction
G-protein coupled receptor signaling pathway
regulation of glucose transport
negative regulation of apoptotic process
hormone secretion
negative regulation of cytokine secretion
negative regulation of inflammatory response
detection of chemical stimulus involved in sensory perception of taste
positive regulation of ERK1 and ERK2 cascade
cellular response to hormone stimulus
response to peptide
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
