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Abnova
GPR143 Polyclonal Antibody, MaxPab™
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产品信息
H00004935-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GPR143 (NP_000264.1, 1 a.a. approximately 424 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTQAGRRGPG TPEPRPRTQP MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR LALGLLQLLP GRRPAGPGSP ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD SVSDMNHTEI WPAAFCVGSA MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM AWGLATLLCV EGAAMLYYPS VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV ASLLKGRQGI YTENERRMGA VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS LKPVRTAAKT TWFIMGILNP AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA HPSPLMPHEN PASGKVSQVG GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT HGDL
靶标信息
Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes. Defects in GPR143 are the cause of ocular albinism type 1 (OA1); also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein coupled receptor 143; ocular albinism 1; Ocular albinism type 1 protein
基因别名: GPR143; NYS6; OA1
UniProt ID: (Human) P51810
Entrez Gene ID: (Human) 4935
eye pigment biosynthetic process
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
visual perception
melanosome localization
melanosome transport
melanosome organization
calcium-mediated signaling using intracellular calcium source
phosphatidylinositol-mediated signaling
regulation of calcium-mediated signaling
regulation of melanosome transport
regulation of melanosome organization
