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Invitrogen
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PA1-25717 detects GRB2 from human, mouse, and rat samples.
PA1-25717 has been successfully used in Western blot procedures.
The PA1-25717 immunogen is residues 1-217 of GRB2.
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2-Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。